Demographic, full lung function and computed tomography (CT) data in a post-coronavirus disease 2019 clinic population at 6-month follow-up, split by lung function phenotype
| All patients | FVC ≥80% pred | FVC <80% pred | DLCO ≥80% pred | DLCO <80% pred | FVC ≥80% and DLCO ≥80% | FVC ≥80% and DLCO <80% “isolated low DLCO” | |
| Patients, n | 78 | 57 | 21 | 21 | 57 | 18 | 39 |
| Age, years | 48.8±12.4 | 47.7±12.7 | 52.3±11.1 | 48.4±2.5 | 49.0±12.7 | 47.6±13.4 | 47.7±11.6 |
| Male | 45 (56) | 30 (52) | 15 (71) | 10 (45) | 35 (61) | 10 (48) | 20 (54) |
| MRC score | |||||||
| 1 | 26 (33) | 19 (33) | 7 (33) | 8 (38) | 18 (32) | 8 (40) | 11 (29) |
| 2 | 26 (33) | 19 (33) | 7 (33) | 4 (19) | 22 (39) | 2 (20) | 17 (41) |
| 3 | 16 (21) | 11 (19) | 5 (24) | 6 (29) | 10 (18) | 6 (30) | 5 (14) |
| 4 | 9 (12) | 7 (12) | 2 (10) | 2(10) | 7 (12) | 1 (5) | 6 (16) |
| 5 | 1 (1) | 1 (2) | 0 | 1 (5) | 0 | 1 (5) | 0 |
| Lung function | |||||||
| FEV1 % pred | 90.3±21.3 | 97.2±17.9 | 71.6±18.8*** | 100±26.1 | 86.8±18.2 | 100.±26.6 | 96.3±10.6 |
| FVC % pred | 93.7±19.7 | NA | NA | 109.2±17.5 | 87.9±17.3 | 111.3±15.2 | 97.3±12.5** |
| FEV1/FVC % | 92.6±16.1 | 98.9±12.8 | 75.0±10.3*** | 104.8±14.4 | 88.3±14.4 | 105.9±13.9 | 95.3±10.6 |
| TLC % pred | 81.2±14.7 | 89.3±9.6 | 65.6±9.5*** | 77.5±96.6 | 96.6±11.7 | 99.8±5.56 | 85.4±7.6 |
| DLCOc % pred | 66.9±18.4 | 73.2±15.7 | 49.4±13.4*** | NA | NA | 90.6±7.2 | 64.8±11 |
| KCOc % pred | 81.6±13.8 | 82.0±12.3 | 80.4±17.4 | NA | NA | 90.3±11.3 | 77.9±10.8 |
| SaO2 % | 96.7±2.2 | 96.8±2.3 | 96.5±1.6 | 96.6±2.3 | 97.3±1.22 | 97.3±1.23 | 96.6±2.57 |
| CT data# | |||||||
| Iodine perfusion | 45.7±15.3 | 46.2±15.6 | 44.2±14.7 | 45.1±10.8 | 45.9±16.8 | 45.0±11.0 | 47.0±17.9 |
| Iodine perfusion (volume-corrected)¶ | 182.8±79.3 | 198±80.8 | 140.2±57.7** | 213±73.8 | 170.9±78.8* | 219.2±69.5 | 186±85.3 |
Data are presented as n, mean±sd or n (%). FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; MRC: Medical Research Council; FEV1: forced expiratory volume in 1 s; TLC: total lung capacity; DLCOc: DLCO corrected for haemoglobin; KCOc: transfer coefficient of the lung for carbon monoxide corrected for haemoglobin; SaO2: arterial oxygen saturation; NA: not appropriate. #: CT measurements included those using noncontrast CT where standard measurements included total lung volume (normal range 5060±1353 mL), mean lung density (normal range −839.6±21.8 HU), Hounsfield units and ground-glass opacification score (normal 3.9±0.58%). Using dual-energy CT, a dynamic comparison was made between a set volume of contrast and noncontrast using whole-lung CT average global iodine perfusion enhancement; ¶: volume adjustment was made per litre of lung volume, to correct for changes in lung volume between subjects. Data compared between columns were significant with *: p<0.05, **: p<0.01, ***: p<0.001.