Selected interferon-γ release assay performance for patients on biologics comparing those with and without any courses of latent tuberculosis (TB) infection treatment, excluding borderline results
Specificity | Sensitivity | NPV | PPV | |
Biologics patients# | 93.96 (93.09–94.75) | 54.55 (40.55 −68.03) | 99.20 (98.83–99.48) | 13.04 (8.98 −18.09) |
Biologics patients never treated for TB¶ | 96.28 (95.52–96.94) | 45.83 (25.55–67.18) | 99.54 (99.21–99.75) | 9.24 (4.71–15.94) |
Data are presented as % (95% CI); data encompass only patients on biologics. NPV: negative predictive value; PPV: positive predictive value. #: including those who may have had TB treatment; ¶: excluded if ever given relevant drugs.