Study intervention in STAR-ter and STAR-too
| Drug | STAR-ter | STAR-too |
| Oral TMP-SMX | BW <40 kg: 8 mg·kg−1 TMP and 40 mg·kg−1 SMX twice daily for 14 days BW ≥40 kg: 320 mg TMP and 1600 mg SMX twice daily for 14 days | BW <40 kg: 8 mg·kg−1 TMP and 40 mg·kg−1 SMX twice daily for 14 days BW ≥40 kg: 320 mg TMP and 1600 mg SMX twice daily for 14 days |
| Oral minocycline (if TMP-SMX allergy)# | BW <50 kg: 2 mg·kg−1 orally twice daily for 14 days BW ≥50 kg: 100 mg twice daily for 14 days | BW <50 kg: 2 mg·kg−1 orally twice daily for 14 days BW ≥50 kg: 100 mg twice daily for 14 days |
| Oral rifampin | None | BW <40 kg: 7 mg·kg−1 (range 5–10 mg) orally twice daily for 14 days BW ≥40 kg: 300 mg twice daily |
| Nasal mupirocin 2% | Apply into each nostril twice daily for the first 5 days | Apply into each nostril twice daily for the first 5 days |
| Oral gargle (0.12% chlorhexidine gluconate wash)¶ | Oral rinse twice daily for 14 days | Oral rinse twice daily for 14 days |
| Chlorhexidine 2% body wipes | None | Once daily for initial 5 days |
TMP-SMX: trimethoprim-sulfamethoxazole; BW: body weight. #: for subjects ≥8 years; ¶: for subjects old enough to gargle.