TABLE 5

Multivariable regression models of forced expiratory volume in 1 s (FEV₁) % pred in the cystic fibrosis (CF) group

Model	Group	Model of	Age (years)		Chronic Pseudomonas aeruginosa^#		Sex (female)		Sweat chloride (mmol·L⁻¹)		HNE ASL FRAP		Model
Model	Group	Model of	β1	p-value	β2	p-value	β3	p-value	β4	p-value	β5	p-value	R²	p-value	β0
1	CF	FEV₁ % pred (n=25)	−1.1	0.001	−22.7	0.007	−10.9	0.12	−0.26	0.05			0.66	<0.0001	145
2	CF	FEV₁ % pred (n=10)^¶	−0.85	0.11	−30.0	0.09	−27.8	0.03	−0.21	0.45	−13.8	0.02	0.91	0.01	187
3	CF	FEV₁ % pred (n=10)^¶	−1.1	0.09	−7.95	0.70	−24.8	0.07	−0.25	0.57			0.76	0.03	142

MCC: mucociliary clearance; P. aeruginosa: Pseudomonas aeruginosa; HNE: human nasal epithelial; ASL: airway surface liquid; FRAP: fluorescence recovery after photobleaching. FEV₁ % pred=β1(age)+β2(P. aeruginosa)+β3(sex)+β4(sweat chloride)+β5(FRAP)+β0. ^#: chronic P. aeruginosa is defined as two or more positive throat or sputum cultures in the previous year; ^¶: only a portion of the CF group had FRAP measurements available (n=10).