Health-related quality of life and cough severity descriptive statistics at baseline and 6-month follow-up
| Baseline (initial) | 6 months (follow-up) | Difference (change) | |||||
| Patients | Summary statistics | Patients | Summary statistics | Patients | Summary statistics | p-value | |
| Time between LCQ at baseline and follow-up (months) | NA | NA | 693 | 6.9 (6.4–7.7) | NA | ||
| Time between NRS-cough at baseline and follow-up (months) | NA | NA | 1565 | 6.6 (6.2–7.5) | NA | ||
| Discrete/continuous variables | |||||||
| LCQ total | 1144 | 12.8±3.0 | 971 | 15.3±3.3 | 806 | 2.5±2.9 | <0.001 |
| LCQ physical | 1194 | 4.3±0.9 | 1008 | 5.0±1.0 | 870 | 0.7±0.9 | <0.001 |
| LCQ psychological | 1228 | 4.5±1.0 | 1034 | 5.2±1.0 | 900 | 0.7±1.0 | <0.001 |
| LCQ social | 1250 | 3.9±1.5 | 1039 | 5.1±1.5 | 929 | 1.2±1.4 | <0.001 |
| NRS-cough 24 h | 2235 | 5.7±2.5 | 1837 | 4.0±2.7 | 1735 | −1.7±3.0 | <0.001 |
| HADS total | 1207 | 8.0 (4–14) | 1024 | 6.0 (2–12) | 886 | −2.0 (−23–29) | <0.001 |
| HADS anxiety | 1229 | 5.0 (2–8) | 1040 | 4.0 (1–6) | 917 | −1 (−3–1) | <0.001 |
| HADS depression | 1239 | 4 (1–7) | 1043 | 2 (1–6) | 922 | −2 (−2–3) | <0.001 |
| Binary categorical variables | |||||||
| LCQ total | 1144 | 971 | 806 | <0.001 | |||
| ≥13 | 540 (47.2) | 762 (78.5) | |||||
| <13 (unfavourable) | 604 (52.8) | 209 (21.5) | |||||
| NRS-cough 24 h | 2235 | 1837 | 1734 | <0.001 | |||
| ≤5 | 1001 (44.8) | 1253 (68.2) | |||||
| >5 (unfavourable) | 1234 (55.2) | 584 (31.8) | |||||
| Cough severity (LCQ and NRS-cough) | 1071 | 909 | 712 | <0.001 | |||
| LCQ ≥13 and NRS-cough ≤5 | 326 (30.4) | 554 (60.9) | |||||
| LCQ ≥13 and NRS-cough >5 | 185 (17.3) | 160 (17.6) | |||||
| LCQ <13 and NRS-cough ≤5 | 131 (12.2) | 49 (5.4) | |||||
| LCQ <13 and NRS-cough >5 | 429 (40.1) | 146 (16.1) | |||||
| HADS total >11 | 1207 | 430 (35.6) | 1024 | 288 (28.1) | 886 | <0.001 | |
| HADS anxiety >11 | 1299 | 99 (8.1) | 1040 | 68 (6.5) | 917 | 0.016 | |
| HADS depression >11 | 1239 | 94 (7.6) | 1043 | 69 (6.6) | 922 | 0.801 | |
Data are presented as n, median (range), mean±sd or n (%), unless otherwise stated. LCQ: Leicester Cough Questionnaire; NRS-cough: Cough Numeric Rating Scale; HADS: Hospital Anxiety and Depression Scale; NA: not applicable.