Demographics of study participants along with pulmonary function, Lung Clearance Index (LCI) and sweat chloride data

CF (n=26)CR (n=16)HC (n=14)p-valuep-value
(CF vs HC)
(CF vs CR)
(CR vs HC)
Age (years)26.5 (19–39)48.0 (44–63.5)22.5 (20–23)0.00010.09<0.0001<0.0001
Female/male (n)14/1210/66/80.560.510.290.43
FEV1 % pred70 (50–93)97 (93–109)102 (95.5–113) (n=12)0.00030.00080.00140.30
FVC % pred94.5 (76–104)104.0 (96–109)107.5 (100–116) (n=12)
FEF25–75% % pred40.5 (22–66)100.5 (74–119.5)83.0 (68–99.5) (n=12)0.00010.0040.00020.29
LCI9.0 (7.6–13) (n=23)7.8 (7.1–8.3)7.2 (6.7–7.5) (n=11)0.00070.00050.010.10
Sweat chloride (mmol·L−1)101 (91–110)36 (21–53) (n=14)22 (10–29) (n=12)0.0001<0.00010.00020.11

Data are presented as median (interquartile range), unless otherwise stated. CF: cystic fibrosis; CR: single CF transmembrane conductance regulator mutation carrier; HC: healthy control; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory flow at 25–75% of FVC; LCI: Lung Clearance Index (from multiple-breath washout testing). p-values comparing all groups by Kruskal–Wallis (nonparametric) except sex which is Chi-squared. Group comparisons by Dunn's test with Holm adjustment (nonparametric, multiple comparisons).