Demographics of study participants along with pulmonary function, Lung Clearance Index (LCI) and sweat chloride data
| CF (n=26) | CR (n=16) | HC (n=14) | p-value | p-value (CF vs HC) | p-value (CF vs CR) | p-value (CR vs HC) | |
| Age (years) | 26.5 (19–39) | 48.0 (44–63.5) | 22.5 (20–23) | 0.0001 | 0.09 | <0.0001 | <0.0001 |
| Female/male (n) | 14/12 | 10/6 | 6/8 | 0.56 | 0.51 | 0.29 | 0.43 |
| FEV1 % pred | 70 (50–93) | 97 (93–109) | 102 (95.5–113) (n=12) | 0.0003 | 0.0008 | 0.0014 | 0.30 |
| FVC % pred | 94.5 (76–104) | 104.0 (96–109) | 107.5 (100–116) (n=12) | 0.02 | 0.01 | 0.05 | 0.23 |
| FEF25–75% % pred | 40.5 (22–66) | 100.5 (74–119.5) | 83.0 (68–99.5) (n=12) | 0.0001 | 0.004 | 0.0002 | 0.29 |
| LCI | 9.0 (7.6–13) (n=23) | 7.8 (7.1–8.3) | 7.2 (6.7–7.5) (n=11) | 0.0007 | 0.0005 | 0.01 | 0.10 |
| Sweat chloride (mmol·L−1) | 101 (91–110) | 36 (21–53) (n=14) | 22 (10–29) (n=12) | 0.0001 | <0.0001 | 0.0002 | 0.11 |
Data are presented as median (interquartile range), unless otherwise stated. CF: cystic fibrosis; CR: single CF transmembrane conductance regulator mutation carrier; HC: healthy control; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory flow at 25–75% of FVC; LCI: Lung Clearance Index (from multiple-breath washout testing). p-values comparing all groups by Kruskal–Wallis (nonparametric) except sex which is Chi-squared. Group comparisons by Dunn's test with Holm adjustment (nonparametric, multiple comparisons).