Characteristics | PAH | CTEPH | All |
Patients, n | 60 | 15 | 75 |
Age, years | 49.1±16.4 | 64.0±13.8 | 52±16.8 |
Female, n (%) | 47 (78.3) | 11 (73.3) | 58 (77.3) |
BMI, kg·m−2 | 28.8±7.3 | 30.4±8.7 | 29.2±7.6 |
WHO-FC, n (%) | |||
Class II | 4 (6.7) | 0 (0) | 4 (5.3) |
Class III | 49 (81.7) | 15 (100) | 64 (85.3) |
Class IV | 7 (11.7) | 0 (0) | 7 (9.3) |
ISWT distance, m | 222±161 | 192±155.9 | 216±159 |
Haemodynamics | |||
mRAP, mmHg | 10±6.2 | 10±5.5 | 10±6.1 |
mPAP, mmHg | 49±13.7 | 42±11.1 | 48±13.3 |
PAWP, mmHg | 10±4.6 | 12±6.4 | 10±5.0 |
Cardiac output, L·min−1 | 4.49±1.60 | 4.26±1.33 | 4.44±1.54 |
Cardiac index, L·min·m−2 | 2.54±0.94 | 2.21±0.58 | 2.46±0.87 |
PVR, dyn·s·cm−5 | 796±401 | 645±322 | 764±388 |
Mixed venous SpO2, % | 64.3±10.7 | 63.0±7.64 | 64.0±10.0 |
Pulmonary function | |||
FEV1, L# | 2.09±0.72 (77% pred) | 2.09±0.82 (82% pred) | 2.09±0.73 (78% pred) |
FVC, L# | 2.82±1.1 (88% pred) | 3.08±1.3 (96% pred) | 2.87±1.1 (90% pred) |
TLCO, mmol·min−1·kPa−1# | 4.41±1.9 (51% pred) | 4.96±1.9 (64% pred) | 4.51±1.8 (54% pred) |
emPHasis10, median (IQR) | 33 (25–41) | 29 (22–36) | 31 (23–39) |
Comorbidities, n (%) | |||
Systemic hypertension | 8 (13.3) | 5 (33.3) | 13 (17.3) |
Atrial fibrillation | 5 (8.3) | 2 (13.3) | 7 (9.3) |
Diabetes | 6 (10) | 2 (13.3) | 8 (10.7) |
Ischaemic heart disease | 2 (3.3) | 1 (6.7) | 3 (4.0) |
COPD | 1 (1.7) | 1 (6.7) | 2 (2.7) |
Interstitial lung disease | 7 (11.7) | 0 (0) | 7 (9.3) |
Chronic kidney disease | 1 (1.7) | 0 (0) | 1 (1.3) |
Data are presented as mean±sd or n (%), unless otherwise stated. emPHasis10 is a patient-reported outcome measure in pulmonary hypertension, scored on a scale of 0–50. PAH: pulmonary arterial hypertension; CTEPH: chronic thromboembolic pulmonary hypertension; BMI: body mass index; WHO-FC: World Health Organization functional class; ISWT: incremental shuttle walk test; mRAP: mean right atrial pressure; mPAP: mean pulmonary arterial pressure; PAWP: pulmonary arterial wedge pressure; PVR: pulmonary vascular resistance; SpO2: oxygen saturation measured by pulse oximetry; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLCO: transfer factor of the lung for carbon monoxide; IQR: interquartile range. #: % predicted values are given in parentheses.