TABLE 1

Baseline characteristics, management and outcomes of the study cohort

Age years61.5 (54.4–71.1)
Sex
 Female66 (42)
 Male90 (58)
Body height cm160.9±9.3
Body weight kg60.3 (53.7–66.6)
Charlson comorbidity index3 (2–5)
Cigarette smoking status
 Never-smoker105 (67)
 Current smoker29 (19)
 Former smoker22 (14)
Time between CT and histologic diagnosis of OP, days13 (7–30)
Method of biopsy
 Surgical91 (58)
 CT-guided percutaneous49 (31)
 Transbronchial forceps15 (10)
 Sonography-guided percutaneous1 (1)
Season of diagnosis
 Spring (March–May)40 (26)
 Summer (June–August)50 (32)
 Autumn (September–November)37 (24)
 Winter (December–February)29 (18)
Aetiology
 Cryptogenic130 (83)
 Secondary26 (17)
  CTD-related14 (9)
   Rheumatoid arthritis6 (4)
   Dermatomyositis/polymyositis3 (2)
   Primary Sjögren's syndrome3 (2)
   Anti-synthetase syndrome1 (1)
   Systemic lupus erythematosus1 (1)
  Drug-related10 (6)
   Amiodarone5 (3)
   Pembrolizumab2 (2)
   Agent(s) in cancer chemotherapeutic regimens2 (2)
   Crizotinib1 (1)
  Post-transplantation2 (2)
Duration of follow-up, weeks120.6 (31.1–269.4)
Treatments
 Observation only45 (29)
 Surgical resection48 (31)
 Corticosteroid alone55 (35)
 Combined corticosteroid and another immunosuppressant7 (4)
 Non-steroid immunosuppressant1 (1)
Needed supplementary oxygen during the course41 (26)
Needed mechanical ventilatory support during the course17 (11)
Outcomes
 Improved without recurrence129 (82)
 Persistent disease11 (7)
 Improved but then recurred5 (3)
 Death11 (8)

Discrete variables are presented as counts (% of the total 156 patients). Continuous variables are presented as mean±sd if normally distributed, and medians (interquartile ranges) if not normally distributed. CT: computed tomography; OP: organising pneumonia; CTD: connective tissue disease.