Baseline characteristics, management and outcomes of the study cohort
Age years | 61.5 (54.4–71.1) |
Sex | |
Female | 66 (42) |
Male | 90 (58) |
Body height cm | 160.9±9.3 |
Body weight kg | 60.3 (53.7–66.6) |
Charlson comorbidity index | 3 (2–5) |
Cigarette smoking status | |
Never-smoker | 105 (67) |
Current smoker | 29 (19) |
Former smoker | 22 (14) |
Time between CT and histologic diagnosis of OP, days | 13 (7–30) |
Method of biopsy | |
Surgical | 91 (58) |
CT-guided percutaneous | 49 (31) |
Transbronchial forceps | 15 (10) |
Sonography-guided percutaneous | 1 (1) |
Season of diagnosis | |
Spring (March–May) | 40 (26) |
Summer (June–August) | 50 (32) |
Autumn (September–November) | 37 (24) |
Winter (December–February) | 29 (18) |
Aetiology | |
Cryptogenic | 130 (83) |
Secondary | 26 (17) |
CTD-related | 14 (9) |
Rheumatoid arthritis | 6 (4) |
Dermatomyositis/polymyositis | 3 (2) |
Primary Sjögren's syndrome | 3 (2) |
Anti-synthetase syndrome | 1 (1) |
Systemic lupus erythematosus | 1 (1) |
Drug-related | 10 (6) |
Amiodarone | 5 (3) |
Pembrolizumab | 2 (2) |
Agent(s) in cancer chemotherapeutic regimens | 2 (2) |
Crizotinib | 1 (1) |
Post-transplantation | 2 (2) |
Duration of follow-up, weeks | 120.6 (31.1–269.4) |
Treatments | |
Observation only | 45 (29) |
Surgical resection | 48 (31) |
Corticosteroid alone | 55 (35) |
Combined corticosteroid and another immunosuppressant | 7 (4) |
Non-steroid immunosuppressant | 1 (1) |
Needed supplementary oxygen during the course | 41 (26) |
Needed mechanical ventilatory support during the course | 17 (11) |
Outcomes | |
Improved without recurrence | 129 (82) |
Persistent disease | 11 (7) |
Improved but then recurred | 5 (3) |
Death | 11 (8) |
Discrete variables are presented as counts (% of the total 156 patients). Continuous variables are presented as mean±sd if normally distributed, and medians (interquartile ranges) if not normally distributed. CT: computed tomography; OP: organising pneumonia; CTD: connective tissue disease.