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Automated lobar quantification of emphysema in patients with severe COPD

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Abstract

Automated lobar quantification of emphysema has not yet been evaluated. Unenhanced 64-slice MDCT was performed in 47 patients evaluated before bronchoscopic lung-volume reduction. CT images reconstructed with a standard (B20) and high-frequency (B50) kernel were analyzed using a dedicated prototype software (MevisPULMO) allowing lobar quantification of emphysema extent. Lobar quantification was obtained following (a) a fully automatic delineation of the lobar limits by the software and (b) a semiautomatic delineation with manual correction of the lobar limits when necessary and was compared with the visual scoring of emphysema severity per lobe. No statistically significant difference existed between automated and semiautomated lobar quantification (p > 0.05 in the five lobes), with differences ranging from 0.4 to 3.9%. The agreement between the two methods (intraclass correlation coefficient, ICC) was excellent for left upper lobe (ICC = 0.94), left lower lobe (ICC = 0.98), and right lower lobe (ICC = 0.80). The agreement was good for right upper lobe (ICC = 0.68) and moderate for middle lobe (IC = 0.53). The Bland and Altman plots confirmed these results. A good agreement was observed between the software and visually assessed lobar predominance of emphysema (kappa 0.78; 95% CI 0.64–0.92). Automated and semiautomated lobar quantifications of emphysema are concordant and show good agreement with visual scoring.

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Authors and Affiliations

  1. Department of Radiology, Calmette Hospital, University of Lille 2, Boulevard Jules Leclerc, 59037, Lille, France

    Marie-Pierre Revel, Jean-Baptiste Faivre, Martine Remy-Jardin, Nunzia Tacelli, Anne-Marie Bakai & Jacques Remy

  2. Department of Respiratory Diseases, Calmette Hospital, University of Lille 2, Boulevard Jules Leclerc, 59037, Lille, France

    Charles-Hugo Marquette

  3. Department of Medical Statistics, Calmette Hospital, University of Lille 2, Boulevard Jules Leclerc, 59037, Lille, France

    Valérie Deken & Alain Duhamel

Authors
  1. Marie-Pierre Revel
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  2. Jean-Baptiste Faivre
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  3. Martine Remy-Jardin
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  4. Valérie Deken
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  5. Alain Duhamel
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  6. Charles-Hugo Marquette
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  7. Nunzia Tacelli
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  8. Anne-Marie Bakai
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  9. Jacques Remy
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Correspondence to Martine Remy-Jardin.

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No financial support to disclose. A potential conflict of interest is noted in that one author is an employee of Siemens.

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Revel, MP., Faivre, JB., Remy-Jardin, M. et al. Automated lobar quantification of emphysema in patients with severe COPD. Eur Radiol 18, 2723–2730 (2008). https://doi.org/10.1007/s00330-008-1065-z

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  • DOI: https://doi.org/10.1007/s00330-008-1065-z

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