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Pulmonary vascular remodeling in pulmonary hypertension

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Abstract

Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension and involves changes in the intima, media and adventitia, often with the interplay of inflammatory cells. This review examines the pathology of these changes and highlights some of the pathogenetic mechanisms that underlie the remodeling process.

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Acknowledgements

The author’s work mentioned in this review was supported by grants R24 HL123767 and P01 HL014985-41A1.

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  1. Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus Research 2, Room 9001, 12700 East 19th Avenue, Aurora, CO 80045, USA

    Rubin M. Tuder

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Correspondence to Rubin M. Tuder.

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Tuder, R.M. Pulmonary vascular remodeling in pulmonary hypertension. Cell Tissue Res 367, 643–649 (2017). https://doi.org/10.1007/s00441-016-2539-y

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