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TRPV4: a Sensor for Homeostasis and Pathological Events in the CNS

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Abstract

Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to calcium, potassium, magnesium, and sodium) that plays an important role in a multitude of physiological processes. TRPV4 is involved in maintaining homeostasis, serves as an osmosensor and thermosensor, can be activated directly by endogenous or exogenous chemical stimuli, and can be activated or sensitized indirectly via intracellular signaling pathways. Additionally, TRPV4 is upregulated in a variety of pathological conditions. In this review, we focus on the role of TRPV4 in mediating homeostasis and pathological events in the central nervous system (CNS). This review is composed of three parts. Section 1 describes the role of TRPV4 in maintaining homeostatic processes, including the volume of body water, ionic concentrations, volume, and the temperature. Section 2 describes the effects of activation and inhibition of TRPV4 in the CNS. Section 3 focuses on the role of TRPV4 during pathological events in CNS.

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Acknowledgements

This work was supported by a grant of the National Research Foundation of Korea (NRF) (NRF-2015H1D3A1066543, NRF-2017R1C1B2011772) and the Korea Healthcare Technology Research & Development Project, Ministry for Health & Welfare Affairs, Republic of Korea (HR16C0002).

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  1. Department of Neurosurgery, CHA University, CHA Bundang Medical Center, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea

    Hemant Kumar & Inbo Han

  2. Department of Biomedical Science, CHA University, Seongnam-si, Gyeonggi-do, Republic of Korea

    Soo-Hong Lee

  3. Department of Neurosurgery, Kyungpook National University Hospital, 130, Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea

    Kyoung-Tae Kim

  4. Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China

    Xiang Zeng

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  1. Hemant Kumar
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Correspondence to Xiang Zeng or Inbo Han.

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Kumar, H., Lee, SH., Kim, KT. et al. TRPV4: a Sensor for Homeostasis and Pathological Events in the CNS. Mol Neurobiol 55, 8695–8708 (2018). https://doi.org/10.1007/s12035-018-0998-8

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