Elsevier

Human Pathology

Volume 28, Issue 12, December 1997, Pages 1383-1386
Human Pathology

Original contribution
Alveolar lipoproteinosis in lung allograft recipients

https://doi.org/10.1016/S0046-8177(97)90228-8Get rights and content

Abstract

Three cases of pulmonary alveolar proteinosis developing in lung allograft recipients are reported. In each case, repeated bouts of alveolar damage from harvest/reperfusion injury, rejection, and infection were observed before the development of intraalveolar accumulation of granular, periodic acid-Schiff-positive material in the allograft lungs. It is speculated that iatrogenic immunosuppression combined with defective clearance of alveolar material by alveolar macrophages created a milieu conducive to the accumulation of surfactant, lipoprotein, and fibrinous debris that was morphologically identical to alveolar proteinosis.

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