Quality of Life and Health Status in Sarcoidosis: A Review of the Literature
Section snippets
Methods
A search using the PubMed database was performed with the key words “sarcoidosis and health status,” “sarcoidosis and quality of life,” and “sarcoidosis and fatigue” for the time period until November 2007. This resulted in 22, 68, and 105 papers, respectively. Only 15 of the papers with the key words “fatigue” and “sarcoidosis” seemed to be relevant studies; the others mainly were case reports or reviews. Fifteen papers found with the key words “sarcoidosis” and “health status” and 14 of
Sarcoidosis quality of life and fatigue
The greatest impact on QOL in sarcoidosis, as seen in clinical practice, is caused by rather nonspecific symptoms hard to objectify, such as fatigue and sleeping disorders [4]. For instance, in one study there seemed to be a number of QOL areas in which sarcoidosis patients, particularly those with current symptoms, experienced problems. Patients either with or without current symptoms suffered from fatigue, sleeping problems, and impaired general QOL compared with a healthy control group.
Discussion
This article focuses on current knowledge of the QOL, HS, and fatigue of sarcoidosis patients. QOL in sarcoidosis is impaired with respect to mobility, working capacity, and activities of daily living, especially in sarcoidosis patients suffering from fatigue and other symptoms, such as breathlessness and arthralgia. HS of sarcoidosis patients is also lower compared with healthy controls, especially in the cognitive aspects, mobility, home management, leisure activities, sleep, social
Summary
The QOL and HS are impaired in patients suffering from sarcoidosis, especially in those with clinical symptoms. Fatigue is an integral part of the clinical picture of sarcoidosis. Although fatigue is a well-known symptom of sarcoidosis, it remains an underestimated problem in clinical practice. Objective test results, such as chest radiographs and laboratory parameters, do not always correlate with the well-being of the patient. Present studies are generally cross-sectional. There is a need for
References (47)
- et al.
Clinical presentation of sarcoidosis in The Netherlands: an epidemiological study
Neth J Med
(1998) - et al.
Evaluation of quality of life in sarcoidosis patients
Respir Med
(1998) - et al.
Assessing health status and quality of life in idiopathic pulmonary fibrosis: which measure should be used?
Respir Med
(2000) - et al.
Fatigue is associated with quality of life in sarcoidosis patients
Chest
(2006) - et al.
Impairment of quality of life: rheumatoid arthritis versus sarcoidosis
Neth J Med
(1999) - et al.
Neurosarcoidosis: a clinical dilemma
Lancet Neurol
(2004) - et al.
Quality of life in patients with active sarcoidosis in Greece
Eur J Intern Med
(2006) - et al.
Health-related quality of life of persons with sarcoidosis
Chest
(2004) - et al.
Six-minute walk test and health status assessment in sarcoidosis
Chest
(2007) - et al.
Assessment of health-related quality of life in patients with interstitial lung disease
Chest
(1999)
Assessment of disease impact in patients with intermittent claudication: discrepancy between health status and quality of life
J Vasc Surg
Importance of differentiating health status from quality of life
Lancet
Quality of life: perception of lung cancer patients
Eur J Cancer
Measuring functional status in chronic lung disease: conclusions from a randomised control trial
Respir Med
The St. George's respiratory questionnaire
Respir Med
Sarcoidosis
N Engl J Med
Quality of life and depressive symptoms in patients suffering from sarcoidosis
Sarcoidosis Vasc Diffuse Lung Dis
Fatigue, quality of life, and health status in sarcoidosis
Eur Respir Mon
Relationship between symptoms and quality of life in a sarcoidosis population
Respiration
Quality of life assessment
The assessment of health status among patients with COPD
Eur Respir J
Quality of life in sarcoidosis: a comparison between members of a patient organization and a random sample
Sarcoidosis Vasc Diffuse Lung Dis
Gender differences in sarcoidosis: symptoms, quality of life and medical consumption
Women Health
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2017, General Hospital PsychiatryCitation Excerpt :Although dyspnea is a common symptom in sarcoidosis, very little has been established regarding the potential impact of psychological, subjective variables on breathlessness severity in this disorder. Several of the studies examined the association of health-related quality of life (HRQL) or anxiety with dyspnea in sarcoidosis [5] [15,16,17]. De Boer et al. found that symptoms of dyspnea were associated with worse HRQL and that the scores of HRQL predicted dyspnea in sarcoidosis [15].
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2015, Clinics in Chest MedicineCitation Excerpt :The impact of any disease depends on the way the patient perceives the disease and modifies his or her activities of daily living. Living with a long-term disease like sarcoidosis significantly affects QoL, with negative consequences for general health and social and psychosocial well-being.3,71–73 QoL is an important outcome measure of treatment, especially with regard to chronic diseases.