Case reportRecurrence of Pulmonary Veno-occlusive Disease After Heart-Lung Transplantation
Section snippets
Case report
A 26-year-old man with pulmonary hypertension was referred in September 2000 to our clinic for evaluation. He had never smoked and had no significant medical or family history. The patient reported severe dyspnea with mild exertion. Echography showed right ventricular hypertrophy and moderate tricuspid regurgitation. Left ventricular function and the mitral valve were normal, and there was no clot in the left atrium. A right-heart catheterization demonstrated severely increased pulmonary artery
Discussion
Pulmonary veno-occlusive disease is a rare cause of pulmonary hypertension. It is more common in children and in young adults and is, in most cases, idiopathic but can also occur as a complication of chemotherapy for malignant disease, of bone marrow transplantation, or of radiotherapy. Recently, a genetic abnormality was found to be associated with pulmonary veno-occlusive disease, revealing a possible pathogenetic connection with primary pulmonary hypertension.1 Dyspnea, fatigue, and
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