Asthma and lower airway diseaseAllergen exposure modifies the relation of sensitization to fraction of exhaled nitric oxide levels in children at risk for allergy and asthma
Section snippets
Study cohort
Study participants were recruited between September 1994 and August 1996. The screening and recruitment of families have been described in detail elsewhere.18 In brief, eligibility criteria included residence in the Boston metropolitan area, maternal age of 18 years or greater, and a history of hay fever, asthma, or allergies in at least 1 of the child’s parents. Families were not screened if the newborn was hospitalized in the intensive care unit, if his or her gestational age was less than 36
Feno measurement
The median level of Feno was 16.0 ppb (range, 2.0-169 ppb) in all subjects with Feno measurements (Table I). On average, children were 11.7 years of age at the time of Feno quantification (age range, 11-13.9 years). Of the 430 children followed to age 12 years by questionnaire, 277 (64%) had Feno measurements. Children with Feno measurements were more likely to be white and less likely to be Hispanic. Distribution of sex and prevalence of maternal asthma were similar for those with versus
Discussion
The importance of ascertaining specific allergic sensitization when evaluating the clinical significance of allergen exposure on asthma morbidity was highlighted, first in the observational National Inner City Asthma Study21, 22 and then in the subsequent intervention study that was targeted at allergen exposures to which asthmatic children were sensitized.23 Our study highlights the importance of allergic sensitization when evaluating the effects of allergen exposures on subclinical pulmonary
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Prenatal exposure to ambient air pollution is associated with early life immune perturbations
2023, Journal of Allergy and Clinical ImmunologyCombination therapy with montelukast and loratadine alleviates pharyngolaryngeal symptoms related to seasonal allergic rhinitis
2019, Journal of Allergy and Clinical Immunology: In PracticeMouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children
2017, Journal of Allergy and Clinical Immunology: In PracticeHigher fractional exhaled nitric oxide and Der p 1 exposure in children with asthma living in tropical environments
2017, Annals of Allergy, Asthma and ImmunologyExhaled nitric oxide in school children: Searching for the lost variability
2016, Allergologia et ImmunopathologiaCitation Excerpt :Gender has been considered as a factor influencing FeNO levels.7,18 However, other studies are in agreement with the results of the present study, which did not find a significant association between FeNO and gender.4 Atopic dermatitis has been previously considered a condition influencing FeNO levels,3 although our regression model has rejected its relevance.
Biomarkers of asthma and allergic airway diseases
2015, Annals of Allergy, Asthma and ImmunologyCitation Excerpt :For example, higher FeNO values were recently identified as a strong predictor of exacerbations in the autumn but not the other seasons.9 Furthermore, a recent birth cohort study found that allergic sensitization to indoor allergens, such as cat, dog, and house dust mite, predicted higher FeNO levels in children, but levels were highest in those children who were not only sensitized but also exposed to the allergen during long periods of sedentary behavior.10 Although studies have shown associations among high FeNO levels (ie, ≥50 ppb), current asthma symptoms, and exacerbations,11 clinical trials of FeNO-guided management have yielded conflicting results.
Disclosure of potential conflict of interest: D. K. Milton and D. R. Gold have received research support from the National Institutes of Health. The rest of the authors have declared that they have no conflict of interest.