Original ArticleLung function at term reflects severity of bronchopulmonary dysplasia
Section snippets
Study design
This prospective study was designed to compare three groups of preterm infants with mild, moderate, and severe BPD, respectively, together with a sample of healthy controls, with respect to four different variables of lung development and function at a postmenstrual age (PMA) corresponding to term. FRC, compliance, resistance of the respiratory system, and gas mixing efficiency were assessed. The study was approved by the Board of Ethics of the Medical Faculty at Göteborg University. Informed
Results
Fifty infants with BPD were included in the study. (Table II) The BPD groups had similar gestational age at birth, birth weight, and PMA at time of study. The control group was more mature at birth, and they had about 1 week greater PMA and body weight at the time of study. There were more females in the mild BPD group and more males in the severe BPD group. However, neither gestational age nor gender contributed significantly to the variance of any of the lung function variables in multiple
Discussion
We measured different aspects of ventilatory function in infants with BPD, classified according to recently proposed criteria, in order to determine if the same variables are affected as are altered by uncomplicated preterm delivery. We also wanted to study whether clinical criteria, based on severity of disease, correlate with different types and degrees of lung involvement when examined close to term. Although the BPD groups had similar gestational ages at birth, the controls were more
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