Elsevier

Respiratory Medicine

Volume 96, Issue 1, January 2002, Pages 24-30
Respiratory Medicine

Regular Article
Extended NO analysis applied to patients with COPD, allergic asthma and allergic rhinitis

https://doi.org/10.1053/rmed.2001.1204Get rights and content
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Abstract

The recommended method to measure exhaled nitric oxide (NO) cannot reveal the source of NO production. We applied a model based on the classical Fick's first law of diffusion to partition NO in the lungs. The aim was to develop a simple and robust solution algorithm with a data quality control feature, and apply it to patients with known alterations in exhaled NO. Subjects with allergic rhinitis, allergic asthma, chronic obstructive pulmonary disease (COPD) smokers and controls were investigated. NO was measured at three expiratory flow rates. An iteration method was developed to partition NO. The airway tissue content of NO was increased in asthma, 144±80 ppb (P=0·04) and decreased in smokers, 56±36 ppb (P=0·02). There was no difference between subjects with rhinitis, 98±40 ppb and controls, 98±44 ppb. The airway transfer rate was increased in allergic asthma and allergic rhinithis, 12±4vs. 12±5 ml sec−1, compared to controls, 8±2 ml sec−1(P<0·001). The alveolar levels were no different from controls, 2±1 ppb. In COPD the alveolar levels were increased, 4±2 ppb (P<0·001). Extended NO analysis reveals from where in the respiratory system NO is generated. Hence, this new test can be added to the tools the physician has for the diagnosis and treatment of patients with respiratory disorders.

Keywords

nitric oxide
asthma
allergic rhinitis
smoker
COPD
airway inflammation
method.

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Correspondence should be addressed to: Dr Marieann Högman, Section of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Box 571, SE 751 23 Uppsala, Sweden. Fax: +46 18 551120; E-mail: [email protected]