Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis
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Quantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
2018, Journal of ProteomicsCitation Excerpt :The protease inhibitory functions of SERPINB3 and B4 provide cellular protection during acute lung injury and inflammation [54]. Previous reports have shown that SERPINB4 plays an important role in epithelial cell proliferation in IPF patients [55], and SERPINB9 is required for normal host-defense responses in the lung, as this protease inhibitor is involved in the cell contact-mediated killing of bacterial and viral pathogens by the immune system [54]. Corticosteroid-binding globulin (CBG or SERPINA6) is mainly involved in the delivery of glucocorticoids to inflamed tissues where proteolysis of CBG by neutrophil elastase releases glucocorticoids in the inflamed areas [56].
Lung cancer in combined pulmonary fibrosis and emphysema: A series of 47 western patients
2014, Journal of Thoracic OncologyCitation Excerpt :The molecular mechanisms underlying the carcinogenesis of lung epithelial cells in patients with CPFE syndrome are yet to be fully determined. The existence of a common genetic susceptibility to emphysema, fibrosis, and lung cancer may be hypothesized as the same germline polymorphisms have been identified for two or three of these conditions, occurring in various genes, including the alpha-nicotinic acetylcholine receptor gene,36 also associated with tobacco-dependence, the telomerase reverse transcriptase gene,37 the fragile histidine triad gene,38 the serpin B4 gene,39 the alpha-1-antitrypsin gene,40 and the surfactant protein A2 gene.41 At the somatic level, tobacco smoking induces numerous molecular alterations in the airway epithelium, both at the expression and genomic level.42,43
Pathology of lung disease: Morphology - pathogenesis - etiology
2021, Pathology of Lung Disease: Morphology - Pathogenesis - Etiology