Abstract
Background: Although smoking is the major risk factor for chronic obstructive pulmonary disease (COPD) many patients with obstructive lung function suggesting COPD are never-smokers. Therefore, other lifestyle factors have been suggested as risk factors.
Aims: i) To examine the association between self-reported intake of fruit and vegetables and risk of COPD and ii) to examine whether the association between these traits are due to underlying genetic factors
Methods: 12,449 twins, aged 40-80, from the Danish Twin Registry were recruited. The participants completed a questionnaire and participated in clinical examination. COPD was defined according to ERS/ATS recommendations. Multivariate logistic regressions were used to examine the association between intake of fruit and vegetables and COPD. Co-twin control analyses were performed to examine whether the association between fruit and vegetables and COPD is explained by genetic factors.
Results: Of the 11,458 individuals were included in the analyses, 48% of the participants were males. Mean age was 58.9 (9.6), mean BMI 26.6 (4.4). A multivariate logistic regression, including sex, age and BMI showed that both smoking, no and heavy drinking and physical inactivity were independent predictors of COPD. There was a significant frequency-pendent association between intake of fruit and vegetables and increased risk of COPD. Conditional logistic regression analyses showed that the association might be controlled by genetic factors.
Conclusions: This study shows that low intake of fruit and vegetables is associated with in increased risk of COPD and the association might be under influence of genetic factors.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, OA1936.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018