Abstract
Background: acute bronchiolitis is frequently diagnosed in infants, involves small airways. It’s often followed by recurrent wheeze. Lung Clearance Index(LCI) is a marker of VI derived from MBW test. It’s more sensible than spirometry indices to detect abnormalities inperipheral lung regions and is easy to obtain also in young children.
Aims: analyze and compare MBW indices among children previously hospitalized for acute bronchiolitis (PB), age-matched healthy controls (HC) and Cystic Fibrosis (CF) children.
Methods: Prospective longitudinal study including PB children hospitalized in our Emergency Department 5-6 years ago, CF with no relevant airway colonization, and HC. Anamnestic and clinical data were collected during follow-up together with LCI, indices of VI arising in the conductive (Scond) and acinar (Sacin) zones, calculated from N2-MBW.
Results: 29 PB,20 CF and 15 HC were recruited. PB had higher LCI levels than HC(p<0.001), and lower than CF(p=0.038 within the 3 groups). Severe bronchiolitis(requiring intensive care) had higher LCI than the others(p=0.019). Scond was higher in PB(p=0.013) children with family history of asthma.
Conclusion: Bronchiolitis could lead to impaired lung function at preschool age. LCI is an easy-to-use sensible marker of ventilation inhomogeneity, also in asymptomatic and non-chronic patients.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, OA3606.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018