Abstract
Introduction: Peripheral muscle weakness and exercise intolerance are prevalent in cystic fibrosis (CF). They were associated with a worse prognosis. Measurement of the maximal isometric voluntary quadriceps force by a dynamometer is commonly used. The one-minute-sit-to-stand test (1STST) has been proposed to evaluate functional exercise capacity and to assess quadriceps strength. However, this test has not been well evaluated in CF. The aim of the study was to correlate the 1STST and the quadriceps force evaluated by the dynamometer in stable patients with CF.
Methods: Patients with CF in stable conditions were recruited to perform the 1STST and the Microfet2dynamometer test to quantify the number of repetitions (1STST) and quadriceps strength (in Newton), respectively.
Results: 34 patients with CF (Age: 37yrs ± 12; body mass index (BMI): 21.7kg/m² [16.4; 33.8]; forced expiratory volume in one second (FEV1): 62% predicted values ± 19) were included. The number of repetitions was 34.9 ± 12.1 and the quadriceps strength was 255.8 ± 127.7N. The 1-STST was correlated to FEV1 (r= 0.497; p=0.003), quadriceps strength (r=0.539; p=0.001) and age (r=0.374; p=0.029) but not to BMI (p=0.518). Quadriceps strength was correlated to height (r=0.344; p=0.047) but not to FEV1 (p=0.774).
Conclusion: The 1STST is a good alternative to the Microfet2dynamometer to estimate quadriceps strength in stable patients with CF. This test is also positively correlated to disease severity contrarily to quadriceps strength, as shown by others (ERJ 2009; 33:99-106). This test could be useful to detect muscular weakness in this population, notably during the routine visit in the CF centres or in primary care.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, OA4991.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018