Abstract
Introduction: Glycaemic variability (GV), a measure of short-term fluctuations in blood glucose levels, has been associated with increased oxidative stress and subsequently implicated in the pathogenesis of microvascular disease. We investigated whether GV was associated with pulmonopathy in people with cystic fibrosis.
Methods: Retrospective analysis of patients undergoing continuous glucose monitoring (CGM) at our regional adult CF centre was undertaken. To avoid a confounding treatment effect those with a previous diagnosis of CFRD were excluded. Contemporaneous baseline characteristics at time of CGM and annual pulmonary function change in the year preceding were recorded. Raw CGM data were then analysed using the EasyGV (Oxford, UK) software. Associations were tested for clinical characteristics and measures of GV (SD = standard deviation, CONGA=Continuous Overall Net Glycaemic Action, MAGE=Mean amplitude of Glycaemic Excursions).
Results: CGMs for 56 patients were analysed (58% female, mean [SD] age 28 [9] years, % predicted FEV1 64.9 [22.0]). All measures of GV showed inverse correlations with baseline FEV1 (SD: r=-0.35, p=0.004, CONGA: r= -0.267, p=0.02, MAGE: -0.318, p=0.009). SD (r=-0.33, p=0.007) and CONGA (r=-2.6, p=0.02) were inversely correlated with baseline weight. Furthermore, CONGA was inversely associated with pulmonary function change in the preceding 12 months (r=-0.28, p=0.017).
Conclusion: In the first study to assess GV and outcomes in CF we found that increased GV appears to be associated with more severe pulmonary function and also accelerated pulmonary decline in the preceding 12 months. Further evaluation of these indices is warranted.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, OA4992.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018