Abstract
Background: transbronchial lung cryo-biopsy is good method of obtaining samples of parenchyma in patients with diffuse parenchymal lung diseases.
Objectives: to evaluate the diagnostic yield and complications of cryobiopsy in a large cohort of patients with a suspected diagnosis of diffuse parenchymal lung disease; in particular, to evaluate the potential correlation between diagnostic yield/complications and procedural aspects/sampling strategies (probe size, site, number of biopsies, etc).
Methods: observational study of 699 cases undergoing TBLC in the clinical-radiological setting of diffuse parenchymal lung diseases with non-diagnostic high resolution computed tomography (HRCT) features.
Results: All patients underwent trans bronchial lung cryo-biopsy. Diagnostic yield is significantly higher when the number of samples increases (p < 0,0001) and when the biopsies are performed in different segments (88% only one segment vs 94% different segments, p < 0,0001). Even pneumothorax seems to be influenced by the number of samples (p 0,008), the site of sampling (p 0,0009) and the baseline FVC (p 0,008), while bleeding is independent by the sampling strategy and the lung function tests. Incidence of pneumothorax is also significantly lower when a 1,9 probe is used (2,7% of cases vs 21.1%, p 0.0001), while bleeding is not influenced by the probe size (p 0,6843). Mortality was observed in 2 patients (0,3%).
Conclusions: this large cohort of patients confirms that cryobiopsy is a safe and good diagnostic approach for obtaining tissue in patients with suspected DPLD.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA2206.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018