Abstract
Right ventricular (RV) function is prognostic relevant for pulmonary hypertension (PH) patients. Unfortunately, its assessment is much more difficult by echocardiography than left ventricular function. Tissue Doppler Echocardiography (TDE) has been suggested as novel non-invasive tool. In this study, we evaluated if TDE differentiates between patients with and without PH and how readouts are associated with cardiopulmonary exercise test derived peak oxygen uptake, right heart catheterization (RHC) derived cardiac index, and the biomarker N-terminal pro brain natriuretic peptide (NT-proBNP).
We included consecutive patients undergoing either diagnostic or follow-up RHC in our PH clinic between 2014 and 2016. Patients underwent clinical evaluation as suggested by PH guidelines. All examinations including TDE were performed within one month. Offline analysis was accomplished by GE EchoPAC.
We included n=179 (females: n=103) patients. N=119 patients had PH (PAH: n=36, PH due to left heart disease: n=21, PH due to lung disease: n=32, chronic thromboembolic PH: n=24, PH by multifactorial causes: n=6) and n=60 patients had no PH. Among the examined RV TDE parameters, tricuspid E/E’ (p<0.01) and segmental peak systolic strain rate (p=0.01) best predicted PH. RV TDE readouts, significantly correlating with peak oxygen uptake, cardiac index and NT-proBNP, included global RV strain (r=0.52, 0.28, 0.44), segmental peak systolic strain rate (r=0.57, 0.32, 0.40), segmental peak systolic strain (r=0.46, 0.21, 0.35), tricuspid A’ (r=0.40, 0.29, 0.49) and RV lateral S’ (r=0.42, 0.35, 0.35).
RV TDE readouts predict PH and are moderately correlated with prognostic relevant parameters associated with RV function in PH.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA3111.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018