Abstract
Background:Hyponatremia is associated with adverse outcome in some cardiopulmonary disease such as left ventricular failure. Probable mechanism in this situation is neurohumoral activation due to hemodynamic instability. However the usefulness of serum sodium level in acute pulmonary embolism (PE) is less well studied.
Objectives: To evaluate the prognostic value of hyponatremia in acute PE.
Methods: From Oct 2016 to Dec 2017, by a prospective study, consecutive patients presented to ED with confirmed acute PE were included. Those with history of CHF and diuretic use were excluded. The patients were divided into two groups: hyponatremic (Na<135) and non-hyponatremic (Na≥135). On-admission pulmonary embolism severity index (PESI) were compared between these two groups. More ever, patients were followed in 30-days in term of all cause mortality. The Independent Sample T-test and Mann-Whitney were used for comparing normally and non-normally distributed quantitative variable respectively. Chi-squared test was used for categorical variables.
Results: Finally, 121 patients completed the follow-up (Age: 54.2±17.8, M/F: 66/55). Hyponatremic patients had significant higher on-admission PESI score and 30-day mortality rate than non-hyponatremic group (110.5±39.3 vs 92.8±40.2, P=0.03 and 32.6% vs 12.3%, p<0.01 respectively). Incidence of on-admission hypotension (SBP<100mmHg) was higher in hyponatremics (20.5% vs 8.2%, P=0.05). However hyponatremia wasn’t associated with cardiac biomarkers, RV enlargement, DVT or in-hospital mortality.
Conclusions: Hyponatremia in patients with acute PE is associated with adverse outcome in terms of in-hospital clinical severity and 30-day mortality rate.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA3120.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018