Abstract
Background: Through a randomized controlled trial (RCT) in 61 lung cancer patients, we demonstrated that 20 weeks of high-intensity training (HIT) after surgery is feasible and improves cardiorespiratory fitness, muscular strength, physical function, body composition, pulmonary function and quality of life (QoL). The aim of this study was to evaluate 5-years survival and long-term effects.
Methods: Thirty-eight patients (63 %), who completed the RCT (HIT vs usual care), were alive 5-years after surgery. Outcomes included the 5-years changes in peak oxygen uptake (VO2peak), 1 repetition maximum (1RM) in muscular strength, total muscle mass by dual-energy x-ray absorptiometry, daily physical functioning and QoL (SF36).
Results: Ten of 30 patients (33%) in the HIT and 13 of 31 patients (42%) in the usual care group died within five years after surgery (p=0.49). Thirty-one patients (82 %) participated in the follow-up. Five years after surgery, the VO2peak was 19.7±6.2 and 18.8±7.0 mL∙kg-1∙min-1 in the HIT and usual care respectively (p=0.71). Mean 5-years change from after surgery in the HIT vs usual care groups are shown in the table.
Conclusions: Twenty weeks of high intensity training shortly after lung cancer surgery had no impact on 5-years survival, but showed persistent effects on leg muscle strength and stair run.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA3372.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018