Abstract
The CD163, a scavenger receptor expressed on macrophages, is known as M2 macrophages marker. M1 and M2 macrophages represent pro- and anti-inflammatory populations, respectively. We reported that CD163 expressed on alveolar macrophages in the lungs of patients with COPD. However, the roles of M2 macrophages in asthma remain unclear. In this study, we investigate the roles of CD163 positive macrophages in lungs of fatal asthma and mouse models of asthma. We used immunohistochemical techniques to examine CD163 expressed on macrophages in the lungs of patients with asthma death (n=7) and nonasthma controls (n=7). The numbers of CD163 positive macrophages in the lung tissues were significantly increased in asthma death patients than seen in control subjects. In mouse models of asthma, airway hyperresponsiveness (AHR) and numbers of eosinophils in the bronchoalveolar lavage fluid (BALF) were significantly decreased in ovalbmin(OVA)-sensitized and challenged CD163 deficient mice, when compared with control wild type mice. Inhibition of CD 163 signaling can be a new treatment target of asthma
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA648.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018