Abstract
Background: It is unclear whether sarcoidosis, a multisystem inflammatory disease, is associated with adverse pregnancy outcomes.
Aim: To assess the risk of adverse maternal and fetal outcomes in sarcoidosis pregnancies.
Methods: Using a population-based cohort study design and Swedish national registers (2002-2013), we identified 764 singleton pregnancies (258 first pregnancies) in the Medical Birth Register with at least one maternal ICD-coded sarcoidosis visit prior to pregnancy in the National Patient Register. Modified Poisson regression models adjusted for age at delivery, calendar year and educational level estimated relative risks (RR) of adverse maternal and fetal outcomes in sarcoidosis pregnancies compared to the general population. Some models were additionally adjusted for body mass index, smoking and comorbidity.
Results: The prevalence of pre-existing diabetes and hypertension was higher in mothers with sarcoidosis than those without sarcoidosis. Mothers with sarcoidosis had slightly elevated risks for caesarean section (RR 1.1; 95%CI 1.0-1.3) and induced labour (RR 1.2; 95%CI 1.1-1.5). Although rare (occurring in <1% of pregnancies), risk for hospitalization for infection was higher in women with sarcoidosis during pregnancy (RR 3.1; 95%CI 1.2-8.1) and <1 year post-delivery (RR 6.2; 95%CI 2.4-16.0). Among first pregnancies, sarcoidosis was associated with a 60% increased risk of preeclampsia (RR 1.6; 95%CI 1.1-2.5). Newborns of mothers with sarcoidosis had a 30% increased risk for preterm birth (RR 1.3; 95%CI 1.0-1.8). There was no significantly increased risk of malformations.
Conclusions: Sarcoidosis is associated with increased risks for some adverse pregnancy outcomes.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, OA5156.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019