Abstract
Introduction: The STARLINER study (NCT03261037) uses a novel digital collaboration platform and aims to assess disease behaviour during the peri-diagnostic period in patients with suspected ILD. Insights from STARLINER may facilitate early, accurate diagnosis and reduce patient travel. Here we present data from a predefined interim analysis.
Methods: Outcomes include FVC measured using daily home spirometry, daily accelerometry, and FVC, 6MWD and PROs measured in hospital. The digital collaboration platform allows clinicians to access and share data between centres for virtual multidisciplinary discussion.
Results: By 5 Oct 2018, 135 patients were enrolled. At interim analysis, 38 patients were diagnosed with ILD: IPF n=25; non-IPF ILD n=13. The Table shows baseline data. Median (range) time from baseline to diagnosis was 5.1 (1–15) and 6.6 (1–32) weeks for IPF and non-IPF ILD, respectively. Median (Q1–Q3) change from baseline to diagnosis for hospital FVC and 6MWD, respectively, was −10.0 mL (−140.0–40.0; n=21) and 0 m (−70.0–40.0; n=17) for IPF and 0 mL (–40.0–90.0; n=13) and −10.0 m (−25.8–10.0; n=7) for non-IPF ILD.
Conclusions: Use of the digital collaboration platform is feasible for community and tertiary sites, and home assessments are generally well accepted by patients. So far, the observed disease behaviour aligns with clinical expectations. Data from all enrolled patients with longer follow-up will be available for the ERS meeting.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1335.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019