Abstract
Background: Iron deficiency(ID) is common in patients with pulmonary hypertension and has been associated with worse clinical outcome.
Aim: This retrospective observational study investigated the prevalence of ID in patients(pts.)with chronic thromboembolic pulmonary hypertension(CTEPH).
Methods: 147pts. with CTEPH and 190pts. with pulmonary arterial hypertension(PAH) were analyzed. ID was defined by ferritin levels<100μg/L or ferritin between 100-299μg/L, transferrin saturation(TSAT)< 20% and raised levels of soluble transferrin receptor (sTfR)(>4.5nmol/L for women, and >5.0nmol/L for men).A sub-analysis of pts. with elevated ferritin levels(>500 μg/L)was performed. Association of ID with laboratory markers,6 minute-walking distance(6MWD), WHO functional class(FC), and hemodynamics was evaluated.
Results: ID was present in 109 CTEPH pts.(74.1%). Mean age was 64.7±15.5 years. In the study group were 78(53.1%) females and 69(46.9%) males. 6MWD was 394.6±129.9m compared with 348.3±130.8m(P=0.016) in a PAH control group. In-depth analysis revealed a significantly higher TSAT in CTEPH (23.2±24.9%) compared with PAH (17.6±12.2%,P =0.008). CTEPH pts. mean levels of hemoglobin(13.3 ± 2.6mmol/L), transferrin(271.8 ± 54.5%) and ferritin(139 ± 280.9μg/L)were similar to those in PAH (13.1±2.6,P=0.370;137.4±311.6,P=0.961;273.8±65.3,P=0.771). ID-CTEPH pts.had lower 6MWD(378.7±130.7m) than non-ID CTEPH pts. without elevated ferritin levels(444.33±121.65m,P =0.046).
Conclusion: There is a high prevalence of ID in CTEPH. This was associated with lower exercise capacity, but did not correlate with WHO FC, hemodynamics and survival.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1443.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019