Abstract
Objective: To evaluate the prognostic significance of a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF) versus not IPF achieved by transbronchial cryiobiopsy.
Methods: 310 consecutive patients evaluated at Pulmonary unit of GB Morgagni Hospital, Forlì, Italy for interstitial lung diseases, without a typical usual interstitial pneumonia pattern on HRCT. All cases underwent lung cryobiopsies between January 2011 and December 2014. Three pathologists reviewed the cases blind to any clinical information. All cases were re-evaluated by clinician, radiologist and pathologist to reach a consensus diagnosis. We used univariate Cox regression analysis to identify associations between mortality and multidisciplinary diagnosis of IPF vs not-IPF.
Measurements and Main Results: 278 cases were included in the analysis. Cryobiopsy was informative in 232 cases (83%). 99 cases(43%) had multidisciplinary diagnosis of IPF, 122 cases(52%) were non-IPF and 11 cases (5%) unclassifiable. Univariate Cox regression analysis showed a significant prognostic separation (HR 3.54, 95% CI 1.81-6.91, p=0.0001) between multidisciplinary IPF diagnosis and not-IPF, similar to pathologic distinction between UIP and non-UIP cases (HR 3.82, 95%CI 1.82-8.01, p=0.0001).
Conclusions: Cryobiopsy for diagnosis of diffuse lung disease is acceptable and good for IPF, as validated by the significant greater prognostic separation of IPF diagnosis compared to non-IPF. Same applies for distinction between UIP and non-UIP by pathology.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA314.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019