Abstract
Rationale: It is unclear if childhood bronchitis is associated with adverse respiratory outcomes in middle-age
Aim: To determine the relationships between childhood bronchitis frequency/duration and clinical outcomes in middle-aged Australians
Methods: Data were from the Tasmanian Longitudinal Health Study (TAHS, 1968-2016). Four categories of parent-reported bronchitis by age 7 were none (reference), non-recurrent, recurrent (>5 episodes of “loose, rattly” or chesty cough lasting <1 month), and recurrent-protracted (>5 episodes, ≥1 month average duration). Outcomes at age 53 included chronic bronchitis (CB), asthma and pre/post-bronchodilator (BD) spirometry. Trend tests, mediation analysis and multivariable regression were used
Results: Increasing childhood bronchitis severity was associated with adult asthma/pneumonia-ever (p-trend<0.001) but not adult current CB. Associations with lung function were less clear. Asthma and FEV1 at age 7 were mediators
Conclusion: Dose-response relationships were seen between increasing childhood bronchitis and outcomes other than bronchitis in middle-age. Further delineation of longitudinal phenotypes is needed
Grant Support: NHMRC; Clifford Craig & Asthma Foundations; GSK; RHH
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4987.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020