Abstract
Background: Lung MRI is a promising tool to monitor early changes in cystic fibrosis (CF). However, there are no data on the ability of functional MRI to assess disease progression in children with CF.
Aim: To evaluate changes in functional lung MRI and lung function over one year in children with CF.
Methods: Children with CF performed multiple breath washout, spirometry and functional lung MRI at baseline and one year later while clinically stable. We evaluated associations between change in ventilation defect percentage (VDP) and perfusion defect percentage (QDP) calculated from Matrix Pencil-MRI with changes in FEV1, lung clearance index (LCI) and structural MRI-Eichinger Score.
Results: Thirty-seven children (mean(SD) age: 10.7 (±3.7) years) had repeated measurements after one year (mean time: 13.0 (±3.7) months). There were no changes in outcomes over the study period: VDP: -0.73%, [95%CI:-2.3; 0.8]; QDP: -0.85%, [-2.2; 0.5]; FEV1: 0.02 z-scores, [-0.2; 0.3]; LCI: -0.44 units, [-1.1; 0.2]; Eichinger-Score: 0.38 [-0.4; 1.2]. The change in VDP correlated moderately with the change in LCI (r: 0.44, p=0.02) and FEV1 (r: -0.51, p=0.007), but less with Eichinger (r:0.34, p=0.079). The change in QDP correlated moderately with change in LCI (r: 0.40, p=0.03) and Eichinger (r:0.39, p=0.045), but not with FEV1 (r: -0.29, p=0.14). In most patients, changes were congruent, in some changes differed.
Conclusion: Changes in ventilation and perfusion defects from MP-MRI were associated with changes in LCI over one year in most children with CF. In children with incongruent changes, functional MRI added complimentary information that helped to understand lung function changes.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2675.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021