Abstract
Aim: Evaluation of the appropriateness of the GLI reference values for an Antwerp population.
Methods: Retrospective analysis of the lung function database on patients attending the Antwerp University Hospital between 2009-2020 for a diagnostic sleep investigation. Subjects with a history of respiratory or cardiac disease, thoracic surgery, malignancy and (ex-)smokers were excluded. We retained 1.311 Caucasians (Male= 68%) with a mean age of 48±12 (SD) (range 18-89) years and BMI of 26±3 kg/m².
Results: The GLI prediction for FEV1/FVC was accurate in males and females of average height, however FEV1/FVC-values were larger than predicted in short and lower in tall subjects (see figure). FEV1 and FVC were significantly underestimated by the GLI prediction in both sexes (mean z-scores of +0.30±0.96 or 104±13 %pred). DLCO was accurately predicted by GLI in males but values were overestimated in females (z-scores of -0.03±0.82 and -0.27±0.84, respectively, p <0.001). This overestimation by GLI increased with increasing age, leading to a measured DLCO <88 %pred in females above 70 years.
Conclusion: Overall, the GLI reference values appropriately predict lung function values of the Antwerp population. However, measured values of FEV1/FVC in tall subjects and DLCO in (especially older) females were lower than predicted, which results in a higher prevalence of obstructive and diffusion disorders in these categories.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2684.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021