Abstract
Introduction: The identification of lung growth patterns and their determinants is important to reduce the global burden of chronic respiratory disease. Particularly the recovery of early life deficits, i.e. catch-up growth in childhood, is insufficiently understood.
Aim: To identify lung function trajectories and their determinants in children aged 4-18 years from the Infancia y Medio Ambiente (INMA) cohort.
Methods: Children with at least two spirometry manoeuvres (n=1223, 49% girls), performed between 4, 7, 9, 10, 11, 14, and 18 years of age, were included to generate standardised lung function trajectories for zFEV1, zFVC and zFEV1/zFVC using Group-Based Trajectory Modelling. Multinominal logistic models were built to identify pre- and postnatal determinants.
Results: Four lung function trajectories were identified for zFEV1, zFVC, and zFEV1/zFVC: catch-up, low, average, and high (Figure 1). Higher levels of physical activity at 4 years were associated with the zFEV1 catch-up trajectory when compared to the low trajectory (odd's ratio: 1.97; 95% CI: 1.02–1.12). Higher maternal age (0.94; 0.89–0.99), allergic disease of children (0.58; 0.36–0.92) and heavy maternal smoking (0.48; 0.23–1.01) significantly reduced the odds of belonging to the high compared to the low zFEV1 trajectory. Similar associations were observed for zFVC and zFEV1/FVC trajectories.
Conclusions: Maternal age and smoking, pediatric allergic diseases, and childrens' physical activity levels are related to lung function growth between 4-18 years.
Figure 1: Catch-up, low, average, and high lung function trajectories for children aged 4–18 years for zFEV1 (panel A), zFVC (panel B) and zFEV1/zFVC (panel C).
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2961.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021