Abstract
The prognosis of interstitial lung disease (ILD) in rheumatoid arthritis (RA) patient is difficult to predict. To determine the prognostic value of automated quantification system (AQS) in patient with RA-ILD.
We analyzed clinical data and high resolution computed tomography (HRCT) images of 144 patients with RA-ILD retrospectively. The quantitative lung fibrosis (QLF, sum of reticulation and traction bronchiectasis) and quantitative ILD (QILD, sum of QLF, honeycombing [QHC] and ground glass opacity [QGG]) scores were measured on HRCT by AQS.
Of all patients, the mean age was 61.2 years, and 43.8% were male, and 5-year mortality was 30.5% (median follow up: 52.2 months). Non-survivors showed older age and higher erythrocyte sedimentation rate (ESR) than survivors. In the multivariable Cox analysis, higher QLF, QHC and QILD scores were independent prognostic factors, along with older age and higher ESR. In the receiver operating characteristic analysis, QLF score showed better performance in predicting 5-year mortality than QHC and QGG scores, but was similar to QILD score (Fig. 1a). Patients with high QLF score (>12% of total lung volume) showed higher 5-year mortality (50% vs 17.4%, p <0.001) than those with low QLF score (Fig. 1b).
QLF score might be useful to predict prognosis in patients with RA-ILD, and high QLF score may differentiate a progressive phenotype with poor survival.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2968.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021