Abstract
Introduction: Extensive consolidation of lung on chest CT scan is associated with worse outcomes in patients with coronavirus disease 2019 (COVID–19) ARDS. We hypothesized that the global lung ultrasound (LUS) score is also associated with outcome.
Aim: To determine the prognostic accuracy of 12 region LUS–derived aeration score in patients with severe COVID–19 ARDS undergoing invasive ventilation.
Methods: This was an international multicenter study. Global LUS–aeration score was calculated as the primary prediction. Secondary predictors were pleural line abnormalities and subpleural consolidations. The primary outcome was successful liberation from the ventilator and secondary outcome mortality at 28 days.
Results: 55 patients were included. Global LUS–aeration score was significantly associated with successful liberation (hazard ratio (HR), 0.87 [95%–confidence interval (CI) 0.81–0.93]; p<0.01) and ICU mortality (HR, 1.12 [95%–CI 1.02–1.23]; p=0.01). For successful liberation the best cutoff was 13 and for mortality 17. Subpleural consolidations and pleural line abnormalities were neither associated with successful liberation, nor mortality.
Conculsions: To conclude, the global LUS–aeration score holds prognostic validity in invasively ventilated COVID–19 ARDS patients. (Sub)pleural abnormalities are not associated with outcome.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA4345.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021