Abstract
Introduction: A recent study reported that patients with interstitial lung disease (ILD) are at increased risk of death from coronavirus disease 2019 (COVID-19). However, there are no study on the outcome of COVID-19 patients with preexisting ILD treated with corticosteroids or antiviral drugs.
Methods: We extracted 26 patients with preexisting ILD by medical records and HRCT pattern. Of 503 patients with COVID-19, we selected 52 patients as control matched for age and sex.
Results: There were statistically no difference between ILD group and non-ILD group in treatment with corticosteroids (76.9% vs. 76.9%; p = 1.000), remdesivir (42.3% vs. 32.7%; p = 0.458), and baricitinib (11.5% vs. 7.7%; p = 0.680), except tocilizumab (26.9% vs. 7.7%; p = 0.036). In ILD group, noninvasive positive-pressure ventilation or high-flow nasal cannula were used more often than in non-ILD group (30.8% vs. 1.9%; p < 0.001). Although mortality rate in ILD group tended higher than in non-ILD patients, no statistical difference was found (11.5% vs. 3.8%; p = 0.326). In univariate analysis to evaluate risk factors for severe condition, diabetes mellitus was only associated with severity of COVID-19 in patients with preexisting ILD. Diagnosis of idiopathic pulmonary fibrosis, usual interstitial pneumonia pattern, and honeycomb lung were not risk factors of severe disease.
Conclusion: Mortality rate was not statistically different between ILD group and non-ILD group. Treatment with corticosteroids, antiviral drugs, and immunosuppressive agents may affect the outcome of COVID-19 patients with ILD.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2254.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021