Abstract
Introduction: Interstitial Lung Diseases are the major cause of mortality in Connective Tissue Diseases.
Aim: To describe patients with Interstitial Lung Disease associated with Connective Tissue Diseases (CTD-ILD).
Methodology: We conducted a single center descriptive cross-sectional study at Central Chest Clinic, Colombo which is the largest chest clinic in the country.
Results: The sample consisted of 83 consecutive patients diagnosed with CTD-ILD. The age ranged from 24 to 72 years, mean (SD) age was 55.6 (10.6) years. The majority was female patients (n=70,88.6%). The majority 53.0% (n=44) hadRheumatoid Arthritis(RA )and Systemic Sclerosis(SSc) as the second commonest (n=22,26.5%). NSIP 51(61.9%) was the most frequently observed HRCT pattern in our cohort whereas UIP was the second commonest. RA-ILD subgroup demonstrated female (n=37, 86.0%) preponderance. NSIP (n=24, 55.8%) was the commonly observed HRCT pattern fallowed by UIP (n=15, 34.9%) pattern. Among RA-ILD patients, 28 (65.1%) had positive Rheumatoid factor. Majority of (n=20, 90.9%) SSc-ILD were females. Sixteen (72.7%) of them had NSIP pattern in HRCT analysis fallowed by UIP (n=6, 27.3%).
Conclusion: To the best of our knowledge this is the first study to describe CTD-ILD patients in Sri Lanka. RA-ILD was the most frequent type of CTD-ILD followed by SSc. The most striking finding is that the predominant NSIP pattern and clear female preponderance in RA-ILD compared to global data. We recommend prospective multicenter studies to be carried out and prospective disease registries to be established to explore the epidemiological, clinical, radiological and prognostic characteristics of CTD‑ ILD in Sri Lanka
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2540.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021