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Original ResearchPulmonary Function TestingInstrument Accuracy and Reproducibility in Measurements of Pulmonary Function
Section snippets
Instruments Tested
This trial was a replicated, fully crossed multifactor, single-center methodology study. The following new instruments were purchased from each of five different manufacturers: Collins CPL (Ferraris Respiratory; Louisville, CO); Morgan Transflow Test PFT System (Morgan Scientific; Haverhill, MA); SensorMedics max 22D (VIASYS Healthcare; Yorba Linda, CA); Jaeger USA Masterscreen Diffusion TP (VIASYS Healthcare); and Medical Graphics Profiler DX System (Medical Graphics Corp; St. Paul, MN).
Results
Tabular summaries of the mean percentage of accuracy of spirometry end points and the mean absolute accuracy of Dlco end points are provided in the on-line supplement to this article.
Discussion
The methodology employed in the current study enabled a uniform assessment of several commercially available PFT instruments in the measurement of spirometry and gas exchange end points. Our results provide insight into the accuracy and reproducibility associated with the measurement of these end points that is due solely to instrumentation.
Instrumentation technology has advanced to the point that the accuracy of spirometric measurements is very similar between instrument models and, in most
ACKNOWLEDGMENT
The authors wish to thank Janet Embry for manuscript review and editing, and Heather Howell and Angie Flint for technical support and data collection. Editorial support was also provided by J. Grice of PAREXEL.
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This study was sponsored by Pfizer Inc.
Drs. Jensen and Crapo have been consultants for Pfizer Inc. and have received royalties from Hans Rudolph Company. Drs. Teeter, England, White, and Pickering are employed by Pfizer Inc.