Chest
Original ResearchCOPDDistance and Oxygen Desaturation During the 6-min Walk Test as Predictors of Long-term Mortality in Patients With COPD
Section snippets
Materials and Methods
A total of 576 outpatients with COPD and wide range of airflow obstruction from clinics in the United States (Bay Pines VA Medical Center, Bay Pines, FL, and Caritas St. Elizabeth's Medical Center, Boston, MA) and Spain (Hospital Universitario La Candelaria, Tenerife, and Hospital Miguel Servet, Zaragoza, Spain) participated in the study, which was approved by the human review boards at each center. Patients were enrolled from December 1995 and were followed up until January 2006. This is part
Results
The cohort of all patients screened and the patients included in the study with the different subgroup analysis are presented in Figure 1. The 576 patients included were distributed as follows: 323 patients (56%) were from the United States (226 from St. Petersburg, FL, and 97 from Boston, MA) and 253 patients (44%) were from Spain (118 from Tenerife and 135 from Zaragoza). Median age was 68 years (range, 51 to 81 years), and most (89%) were men. At entry time using the ATS-ERS/Global
Discussion
This study presents two novel findings. First, it demonstrates for the first time that in patients with a wide range of airflow obstruction the 6MWD is an important prognostic factor primarily in patients with severe COPD (FEV1 < 50% of predicted). Secondly, our study showed that oxygen desaturation during the 6MWD may have a possible small additive role to the distance walked in helping predict mortality but is not as useful as the determination of the Pao2.
The new guidelines for COPD
References (24)
- et al.
Distance and oxygen desaturation in 6-min walk test predict prognosis in COPD patients
Respir Med
(2007) - et al.
Validation of a combined comorbidity index
J Clin Epidemiol
(1994) - et al.
Ventilation and gas exchange during sleep and exercise in severe COPD
Chest
(1996) - et al.
Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
Eur Respir J
(2004) - et al.
Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary
Am J Respir Crit Care Med
(2001) - et al.
The body mass index, airflow obstruction, dyspnea, exercise performance (BODE) index in chronic obstructive pulmonary disease
N Engl J Med
(2004) ATS statement: guidelines for the six-minute walk test
Am J Respir Crit Care Med
(2002)- et al.
Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population-based cohort study
Thorax
(2006) - et al.
The 6-min walk distance: change over time and value as a predictor of survival in severe COPD
Eur Respir J
(2004) - et al.
NETT Research Group: predictors of mortality in patients with emphysema and severe airflow obstruction
Am J Respir Crit Care Med
(2006)
Clinical correlates and prognostic significance of 6 minute walk in patients with pulmonary hypertension: comparison with cardiopulmonary exercise testing
Am J Respir Crit Care Med
Six-minute walk, maximal exercise test: reproducibility in fibrotic interstitial pneumonia
Am J Respir Crit Care Med
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