Chest
Original ResearchCoughAssociated Factors in Children With Chronic Cough
Section snippets
Patients
Children with a cough duration of > 8 weeks were referred to the Pediatric Specialty Center at West Jefferson Medical Center and underwent the workup. They were all from the same geographic area. Patients were evaluated by and workup was directed by the same pulmonologist, gastroenterologist, allergist, immunologist, and otorhinolaryngologist. For inclusion in the study, the children had to have been born full term, be neurodevelopmentally appropriate for age, with no direct or indirect
Results
Forty consecutive children (mean age, 7.8 years; age range, 5 to 12 years; 17 were female, and 23 were male) fulfilling all entry criteria were included in the study. The duration of cough ranged from 8 to 36 weeks (mean [± SD] duration, 18 ± 6 weeks). The associated factors are listed in Table 1. One or more associated and potentially causative factors were identified in 90% of children. The single most common factor associated with chronic cough by itself was gastroesophageal reflux disease
Discussion
This is the first study to comprehensively evaluate children with chronic cough and without a selective workup. Our study suggests that among children with chronic cough (ie, cough of > 8 weeks duration), the most common likely causative factors were allergy, reflux, and asthma. Most children with allergy were found to have upper airway cough syndrome (previously designated as postnasal drip syndrome). Nocturnal cough was more common in the asthma and allergy groups compared with the reflux
Acknowledgments
Author contributions: Drs. Khoshoo, Edell, Haydel, and Saturno conceived the study, developed the protocol, and managed the patients. Ms. Mohnot and Dr. Kobernick contributed to the data analysis. Dr. Khoshoo wrote the first draft.
Financial/nonfinancial disclosures: The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
References (0)
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2018, Principles and Practice of Pediatric Infectious DiseasesEtiologies of Chronic Cough in Pediatric Cohorts: CHEST Guideline and Expert Panel Report
2017, ChestCitation Excerpt :Data were extracted by a single author (A. C.) and checked by a second author (J. O.). For cohort studies, we reported on the study’s setting, number enrolled and completing the study, inclusion and exclusion criteria, as well as other factors (Table 121-32) we considered important for interpretation of studies on chronic cough specific to the KQs. These factors included a definition for diagnoses, how cough was measured and resolution defined, and whether or not the period effect was considered a priori.
Cough in children
2014, Archivos de BronconeumologiaCitation Excerpt :Exposure to tobacco smoke and other environmental contaminants and smoking by the children and adolescents themselves are a common cause of cough or the failure of cough to resolve at all ages.4 Sometimes there may be more than one underlying cause, and an integral etiological approach to this disease in children is fundamental in order to assign appropriate treatment.16–21 One way of approaching cough in children is to evaluate it according to the length of time that symptoms have been present.
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2014, New England Journal of MedicineCitation Excerpt :Common causes of prolonged cough include asthma, gastroesophageal reflux disease, and the upper-airway cough syndrome (Table 1). Together, these causes accounted for 64% of the diagnoses in a prospective study of children with chronic cough.3 Other causes include passive or active smoking, cystic fibrosis, foreign-body aspiration, extrinsic airway compression, and interstitial lung disease.4,5
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2022, Gastroesophageal Reflux in Children: Second Edition
This article was presented in part at the Annual Conference of American College of Chest Physicians, Chicago, IL, October 24, 2007.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/site/misc/reprints.xhtml).