Chest
Original ResearchObstructive Lung DiseasesFactors Associated With Bronchiectasis in Patients With COPD
Section snippets
Study Subjects
The study prospectively included 106 consecutive patients diagnosed with COPD, according to international standards, in our specialist outpatient clinic between January 2004 and December 2006. COPD was defined as a postbronchodilator ratio of FEV1/FVC < 70%, adjusted for age and height in a patient with a smoking habit of > 10 pack-years and β2-agonist reversibility on predicted FEV1 of < 15% and/or 200 mL. COPD was defined as moderate if the postbronchodilator FEV1 was ≤ 70% and severe if the
Results
One-hundred six patients with moderate to severe COPD were analyzed. Eight were excluded from the study because of previous diagnoses of bronchiectasis, four were unable to undergo HRCT scan, and two had uninterpretable HRCT scan results. Of the 92 patients remaining in the study (mean age 71.3 [9.3] years; 99% men), 51 (55.4%) had severe COPD and 41 (44.6%) had moderate COPD. Fifty-three patients (57.6%) presented bronchiectasis (72.5% of the subjects with severe COPD and 34.7% of the subjects
Discussion
Based on our results, the presence of a severe airflow obstruction (FEV1 ≤ 50%), a positive culture of a PPM from a sputum sample, and at least one hospital admission for acute exacerbation in the previous year are factors independently associated with bronchiectasis in patients with moderate or severe COPD.
The prevalence of bronchiectasis in patients with moderate to severe COPD in this study was 57.6%; it was primarily of a cylindric type, localized in the lower lobes, with a frequency
Acknowledgments
Author contributions: Dr Martínez-García: contributed to the design of the study and the collection and analysis of the data; he is also the main author of the manuscript.
Dr Soler-Cataluña: contributed to the design of the study, the collection and analysis of the data, and review of the manuscript.
Dr Donat Sanz: contributed to data collection and the writing of the manuscript.
Dr Catalán Serra: contributed to data collection and the writing of the manuscript.
Dr Agramunt Lerma: contributed to
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Funding/Support: This work was supported in part by a public grant from the Sociedad Valenciana de Neumología.
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