Chest
Original ResearchSleep DisordersSleep Apnea and Glucose Metabolism: A Long-term Follow-up in a Community-Based Sample
Section snippets
Population
From a population-based sample of men who had responded to postal questionnaires in 1984 and 1994, an age-stratified sample of 232 underwent a whole-night sleep recording during 1996 to 1998 in a study of snoring and SDB in individuals with and without hypertension.17 Their mean age was 60.6 years (range, 43-82 years), and one-half were being treated for hypertension. In 2008, 43 of the men had died, and the remaining 189 men were invited to this longitudinal study. In all, 156 (82.5%) agreed
Results
At the follow-up, 23 men (16.3%) fulfilled the criteria for diabetes mellitus. Eleven were taking oral antidiabetic drugs and one in combination with insulin. The characteristics of the participants and differences between those with and without incident diabetes are presented in Table 1. The men who had developed diabetes were of a similar age and had similar smoking habits to the remaining participants but generally were more obese and more often had hypertension. The groups did not
Discussion
The results of this follow-up study demonstrate that SDB has negative effects on glucose metabolism and insulin sensitivity. At follow-up after > 11 years, all the analyzed variables of SDB were significant, independent predictors of a low ISI and of impairment in insulin sensitivity. SDB reached borderline significance for the development of manifest diabetes.
Cross-sectional studies have clearly shown a link between SDB and abnormal glucose metabolism,3, 4, 5, 6, 7, 8, 9 but the evidence
Acknowledgments
Author contributions: Dr Lindberg had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Lindberg: contributed to the study concept and design; data acquisition, analysis, and interpretation; drafting and revision of the manuscript; and review and approval of the final manuscript.
Dr Theorell-Haglöw: contributed to the study concept and design, data acquisition and interpretation, drafting and revision of
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Funding/Support: The study was funded by the Swedish Heart Lung Foundation and the Uppsala County Association against Heart and Lung Diseases.
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