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Clinical InvestigationsEffects of Long-term Oxygen Therapy on Pulmonary Hemodynamics in COPD Patients: A 6-Year Prospective Study
Section snippets
Materials and Methods
Ninety-five consecutive COPD patients, 72 male and 23 female, who were qualified for LTOT between 1986 and 1991, participated in the study. The diagnosis of COPD was based on generally accepted criteria.15 Qualification criteria for LTOT were described elsewhere.16 Briefly, to qualify, patients had to present with stable hypoxemia (PaO2<55 mm Hg) assessed in the steady-state period of the disease. Also patients with moderate hypoxemia (PaO2=56 to 65 mm Hg) were accepted for LTOT if signs of
Results
From 95 enrolled patients, 73 survived 2 years. Thirty-nine subjects agreed to be catheterized again. On average, they had been using oxygen for 14.7 h/d. Results of the initial and the second catheterization are shown in Table 3. There were no significant changes in the studied variables.
Thirty-one patients completed 4 years of LTOT. Twenty-one agreed to have the third pulmonary catheterization. The average oxygen use in that group was 13.5 h/d. The results of all three catheterizations
Discussion
To our knowledge, this is the longest prospective study describing effects of breathing supplemental oxygen on pulmonary hemodynamics in patients with severe COPD, complicated by hypoxic PH. The results of our investigation are strengthened by intermediate data taken at regular intervals. The study has clearly shown that LTOT administered for approximately 14 h/d induced a small reduction of PH during the first 2 years of LTOT. Thereafter, PH returned to the initial level and showed
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2019, Veterinary JournalCitation Excerpt :Presumptive diagnoses of RD/H in dogs with PH are often made solely on the presence of respiratory clinical signs and by exclusion of left-sided heart disease in dogs without diagnostics to definitively determine the underlying etiology (Kellihan et al., 2011; Vezzosi et al., 2018b). Thorough characterization of canine RD/H phenotypes (i.e., into obstructive or restrictive lung disease categories) in dogs with PH could impact treatment and prognosis as it does in people (Zielinski et al., 1998; Alchanatis et al., 2001; Sajkov et al., 2002; Collard et al., 2007; Rietema et al., 2008; Blanco et al., 2010; Corte et al., 2010; Hurdman et al., 2012; Zimmermann et al., 2014). Using pulmonary function testing in people, obstructive lung disease is associated with decreased airflow, whereas restrictive lung disease is associated with decreased lung volume (Gold and Koth, 2016).
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