Chest
Clinical InvestigationsInfectionMycobacterial Infections in Lung Transplant Recipients
Section snippets
Study Design
A retrospective review of medical records was conducted for all lung transplant recipients who had transplants between November 1983 and February 1996. Subjects who had positive cultures for mycobacterium or staining positive for acid-fast bacilli were included. The following information was recorded: isolation and identification of organism before and after transplantation, clinical manifestations of disease following transplantation, treatment prescribed, response to treatment, and outcomes
Patient Population
The records of 210 recipients (210 first transplants and 9 retransplant procedures) were reviewed. There were 159 double lung transplants and 60 single lung transplants. There were eight patients with evidence of mycobacterial infection (3.8%), all of whom received a double lung transplant. Of the eight patients, five were men and three were women. The age range was between 26 and 63 years. The reasons for transplantation were obstructive lung disease (six), cystic fibrosis (one), and pulmonary
Discussion
Mycobacterial infections have been reported in patients with organ transplants, chronic lung disease, and in patients with AIDS. Immunosuppression increases the risk for mycobacterial infection.1,2,3,6,7 We have reported our experience with mycobacterium in 219 transplant procedures. In our series, mycobacterium has been documented in only 3.8% of cases. Two of the patients in our series had indolent disease without extrathoracic signs or symptoms and responded well to treatment. No changes in
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Cited by (94)
Thoracic Infections in Solid Organ Transplants: Radiological Features and Approach to Diagnosis
2022, Radiologic Clinics of North AmericaCitation Excerpt :The overall incidence of NTM infection is between 3.8% and 22.4% and occurs, on average, 2 years after LT.4 However, most isolates occur in asymptomatic patients and are transient with the frequent sites of infection being the skin, subcutaneous tissues, and the lungs.25,26 The most common NTM organisms in LTRs are Mycobacterium avium complex (69.8%) followed by Mycobacterium abscessus (9.4%) and Mycobacterium gordonae (7.5%).27 Donor lung allografts are a major source of transmission, although infection can also arise from reactivation in the native lung after single LTR and from primary infection.27,28
The pulmonary nodule following lung transplantation
2021, Clinical ImagingManagement of Mycobacterium Other than Tuberculosis in Solid Organ Transplantation
2018, Infectious Disease Clinics of North AmericaFirst multicenter study of nontuberculous mycobacteria and/or Aspergillus infections in lung transplant recipients in Japan
2018, Respiratory InvestigationNontuberculous mycobacterial and Aspergillus infections among cadaveric lung transplant recipients in Japan
2018, Respiratory InvestigationNon-tuberculous mycobacterial infections in solid organ transplant recipients: An update
2016, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases