Chest
Clinical InvestigationsCystic FibrosisHypoxemia and Hypercapnia During Exercise and Sleep in Patients With Cystic Fibrosis
Section snippets
Subjects
Patients attending the Alfred Hospital Adult Cystic Fibrosis Service and healthy control subjects were invited to participate in the study. Patients with CF of either sex were eligible for inclusion in the study if they were ≥ 18 years of age, with FEV1 < 60% of predicted normal, Pao2 > 55 mm Hg at rest, not receiving domiciliary oxygen, and in a clinically stable condition as indicated by no hospital admission or change in medications for ≥ 4 weeks. The healthy subjects recruited were matched
Subject Characteristics
Fourteen patients with CF (9 men and 5 women), and 8 control subjects (4 men and 4 women) participated in the study (Table 1). Pao2 was significantly lower in the CF group (67 ± 8 vs 99 ± 4 mm Hg; p < 0.0001); however, there were no significant differences in Paco2 or pH (Table 1). Compared with control subjects, the patients with CF had significantly lower FEV1, FVC, and FEV1/FVC, and significantly greater RV (Table 1). Neither TLC nor Dlco were significantly different between groups. The
Discussion
The major findings of the current study were fourfold. First, hypoxemia and hypercapnia occurred during exercise and sleep to a greater degree in stable, nonhypoxic adult patients with CF, despite normal respiratory muscle strength, than in control subjects. Second, in the CF group, pulmonary function, respiratory muscle strength, and nutritional status correlated with maximum workload during exercise but not with levels of hypoxemia or hypercapnia that occurred during exercise. Third, in the
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Dr. Solin is a recipient of an Australian National Health and Medical Research Council scholarship. Matthew Naughton is a recipient of an Astra/Australian Lung Foundation Career Development Award and Viertal Clinical Investigatorship.