Chest
Clinical InvestigationsTHE PLEURASuccessful Talc Slurry Pleurodesis in Patients With Nonmalignant Pleural Effusion
Section snippets
Patients
From 1992 to 1997, we treated 16 patients with chemical pleurodesis (Table 1). Patients referred to the pulmonary clinic or seen as inpatients at Hadassah University Hospital, Jerusalem, Israel, were considered candidates for chemical pleurodesis if they had a large (usually one third of the pleural cavity) symptomatic effusion that required therapeutic thoracocentesis at least once a month.
Pleurodesis Technique
A chest drain was inserted in all cases. On nine occasions, the patient was hospitalized for 2 to 5 days,
Results
There were eight men and eight women, ages 21 to 87 years (median, 66 years) (Table 1). The diagnosis for which pleurodesis was performed included CHF in 6 patients, liver cirrhosis in 4, systemic lupus erythematosus (SLE) in 1, yellow nail syndrome (YNS) in 1, chylothorax in 1, and in 3 patients, the cause of effusion was unknown. In five instances, the effusion was exudative, and in 11, it was transudative. All patients had multiple pleural taps (2 to 50; mean, 6) before pleurodesis. In 13
Discussion
The present study demonstrates that the intrapleural administration of 2 to 3 g of talc in a slurry was an effective treatment for nonmalignant recurrent pleural effusion. In previous studies, talc slurry has been very effective in treating malignant pleural effusion and pneumothorax. There are > 600 reported cases of talc used in the treatment of pneumothorax and > 650 in primary or secondary malignant pleural effusion.2, 34, 89, 10 Talc has been used less frequently for the treatment of
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Cited by (70)
Diagnosis and Treatment of Pleural Effusion. Recommendations of the Spanish Society of Pulmonology and Thoracic Surgery. Update 2022
2023, Archivos de BronconeumologiaDetermination of In Vivo efficacy and safety of zeolite as a new pleurodesis agent
2022, Toxicology ReportsCitation Excerpt :Elimination of the pleural space helps decrease the symptoms and improve the patient’s quality of life. Using either chemical or mechanical methods, pleurodesis can be performed for patients with both malignant [25,35,6] and non-malignant pleural effusions [10,34]. The most commonly used chemical pleurodesis agents include povidone-iodide [11,30], bleomycin [28], silver nitrate [32,36], tetracycline [1,32], autologous blood patch [7], and talc [14,37,41].
Pleurodesis
2021, Encyclopedia of Respiratory Medicine, Second EditionPleural effusions of urinary etiologies
2019, Disease-a-MonthCitation Excerpt :The most common reason for a pleural effusion is low oncotic pressure due to proteinuria and increased hydrostatic pressure because of salt retention.9 The decreased oncotic pressure occurs in the pleural microvasculature causing the fluid leakage, this is further exacerbated by salt and fluid overload.10 The presence of a pleural effusion should also raise the suspicion of a pulmonary embolism, especially if the effusion is exudative or hemorrhagic in nature.10,11
Diagnosis and Management of Pleural Transudates
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