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Clinical InvestigationsSleep and BreathingMandibular Advancement Device in Patients With Obstructive Sleep Apnea: Long-term Effects on Apnea and Sleep
Section snippets
Subjects
Thirty-three consecutive patients who received treatment with mandibular advancement devices from September 1989 until March 1994 were included in the study. The patients suffered from mild sleep apnea or more severe disease and were unable to tolerate treatment with nasal continuous positive airway pressure. There were 29 men and 4 women aged 52 ± 11 years (mean ± SD) at the onset of treatment. Approval for the participation of the patients in the study was obtained from the Medical Ethics
Results
Thirty-three patients with obstructive sleep apnea were evaluated for the short-term effects of a mandibular advancement device on apneas and sleep. Nineteen of the 33 patients were still using their mandibular advancement devices at the long-term follow-up visit after 5.2 ± 0.4 years (range, 4.5 to 6.1 years) and reported that they had used their devices for 50 to 90% of the nights since the onset of treatment. There were 17 men and 2 women among these long-term treatment patients. The age of
Discussion
At the long-term follow-up visit, the apnea-hypopnea index was reduced from 22 ± 17 events per hour without the device to 4.9 ± 5.1 events per hour with the device in 19 patients with sleep apnea who received treatment with mandibular advancement devices for 5.2 ± 0.4 years. This result was similar to the findings at the short-term follow-up visit after 0.7 ± 0.5 years. Patients who had replaced or adjusted their devices during the study period experienced a better apnea reduction at the
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Cited by (104)
Avoiding and Managing Oral Appliance Therapy Side Effects
2020, Sleep Medicine ClinicsOral Appliances for Snoring and Obstructive Sleep Apnea
2020, Otolaryngologic Clinics of North AmericaEfficacy and tolerability of a custom-made Narval mandibular repositioning device for the treatment of obstructive sleep apnea: ORCADES study 2-year follow-up data
2019, Sleep MedicineCitation Excerpt :Several studies have investigated the long-term effects of MRD in OSAS, but included only a small number of mild to moderate OSAS patients [24–29]. Larger comparative [19,30–32] or noncomparative [24,26,33,34] trials evaluated an MRD as first-line therapy, but only one reported long-term data in CPAP-intolerant patients [35]. The purpose of the five-year ORCADES study is to provide long-term evaluation of MRD as second-line treatment of OSAS in patients with a range of disease severity.
Avoiding and Managing Oral Appliance Therapy Side Effects
2018, Sleep Medicine Clinics
The study was conducted at the Sleep Laboratory at the Departmentof Respiratory Medicine, University Hospital, Umeå, Sweden.
Support was provided by grants from the Swedish Association for Heartand Lung Patients and the Swedish Dental Society.