Chest
Clinical InvestigationsHIVRespiratory Symptoms Among HIV-Seropositive Individualsa
Section snippets
Subjects and Study Protocol
Three hundred twenty-seven HIV-seropositive subjects with no history of AIDS-related pulmonary complications comprised a cohort participating in a longitudinal study evaluating pulmonary physiology, respiratory symptoms, and chest CT. Data included in this report represent baseline data and were collected between 1993 and 1998. All subjects completed the ATS-DLD questionnaire and underwent pulmonary function testing. All subjects provided written consent under an approved protocol of The Ohio
Baseline Demographics and Clinical Variables
Table 2summarizes the demographic data in both groups. As demonstrated in the table, there was no significant difference in age between the two study groups. In addition, the majority of subjects were white and male, and the groups were also similar with respect to sex and race (data not shown). Of note, the BMI, despite being normal (100.3 ± 1.0% of predicted), was significantly lower in the HIV-seropositive group. The prevalence of cigarette smoking was approximately equal in both groups;
Discussion
Over the course of the HIV epidemic, pulmonary complications have been an important source of morbidity and mortality in this patient population. Both infectious and noninfectious complications have been well described.1112However, evidence exists that HIV-infected individuals may acquire unexplained alterations in pulmonary function12and high-resolution chest CT131415independent of or prior to overt pulmonary complications. Our current study examining the results of the ATS-DLD respiratory
Acknowledgment
The authors thank Tina Bees for assistance with manuscript preparation.
References (22)
- et al.
Reference data for obesity: 85th and 95th percentiles of body mass index (wt/ht2) and triceps skin fold thickness
Am J Clin Nutr
(1991) - et al.
Assessment of right ventricular function and pulmonary artery circulation by cine-MRI in patients with AIDS
Chest
(1996) - et al.
Pulmonary function human in immunodeficiency virus infection: a prospective 18 month study of serial lung function in 474 patients
Am Rev Respir Dis
(1992) - et al.
Pulmonary function tests in HIV-infected patients without AIDS
Am J Respir Crit Care Med
(1995) - et al.
Quality of life in persons with human immunodeficiency virus infection: measurements by the medical outcomes study instrument
Ann Intern Med
(1992) - et al.
Latent adenovirus infection in the pathogenesis of chronic airways obstruction
Am Rev Respir Dis
(1992) - et al.
Acute lower respiratory illness in childhood as a predictor of lung function and chronic respiratory symptoms
Am Rev Respir Dis
(1989) Epidemiology Standardization Project (American Thoracic Society)
Am Rev Respir Dis
(1978)- et al.
The maximal expiratory flow-volume curve: normal standards, variability, and effects of age
Am Rev Respir Dis
(1976) - et al.
Respiratory function test: normal values at median altitudes and prediction of normal results
Am Rev Tuberc
(1959)
Single-breath carbon monoxide diffusing capacity prediction equations from a Mediterranean population
Am Rev Respir Dis
Cited by (82)
Pulmonary Function in People Living With Human Immunodeficiency Virus: A Meta-Analysis
2024, Archivos de BronconeumologiaDesign and methods of a randomized trial testing the novel Wellness Intervention for Smokers Living with HIV (WISH)
2021, Contemporary Clinical TrialsHIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype
2017, Cell ReportsCitation Excerpt :With the development of effective anti-retroviral therapy (ART), the survival of individuals infected with HIV-1 has been dramatically improved (Murphy et al., 2001; Palella et al., 1998). However, chronic HIV-1 infection is associated with several comorbid disorders, including a high incidence of COPD manifesting as emphysema (Bhatia and Chow, 2016; Bhatia et al., 2012; Crothers et al., 2006, 2011; Diaz et al., 1992, 2000, 2003; Giantsou, 2011; Kalim et al., 2008; Morris et al., 2011a, 2011b; Naicker et al., 2015; Palella and Phair, 2011; Petrache et al., 2008). The pathogenesis of HIV-associated emphysema is not well understood, with some evidence implicating lung destruction mediated by AMs, CD8 T cells, HIV envelope proteins, and possibly anti-retroviral drugs (Buhl et al., 1993; George et al., 2009; Green et al., 2014; Kanmogne et al., 2005; Park et al., 2001; Plata et al., 1987; Twigg et al., 1999).
Association Between HIV and Prevalence and Manifestations of Asthma: Analysis of the Multicenter AIDS Cohort Study and Women's Interagency HIV Study
2022, Journal of Acquired Immune Deficiency SyndromesImpaired differentiation of small airway basal stem/progenitor cells in people living with HIV
2022, Scientific Reports
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (e-mail: [email protected]).
Supported by National Institutes of Health, National Heart, Lung, and Blood Institute grants RO1 49730 and RO1 53229, and The Ohio State University General Clinical Research Center grant MO1 RR00034.